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A surgeon's guide to anticoagulant and antiplatelet medications part one: warfarin and new direct oral anticoagulant medications
  1. Paul B McBeth1,
  2. Jordan A Weinberg2,
  3. Babak Sarani3,
  4. Louise Y Y Yeung4,
  5. Addison K May5
  1. 1Departments of Surgery and Critical Care Medicine, University of Calgary, Calgary, Alberta, Canada
  2. 2Department of Surgery, Dignity Health/St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA
  3. 3Center for Trauma and Critical Care, George Washington University, Washington DC, USA
  4. 4Kaiser Permanente, Los Angeles, California, USA
  5. 5Division of Trauma and Surgical Critical Care, Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
  1. Correspondence to Dr Addison K May; addison.may{at}


An increasing number of potent antiplatelet and anticoagulant medications are being used for the long-term management of cardiac, cerebrovascular, and peripheral vascular conditions. Management of these medications in the perioperative and peri-injury settings can be challenging for surgeons, mandating an understanding of these agents and the risks and benefits of various management strategies. In this two-part review, agents commonly encounter by surgeons in the perioperative and peri-injury settings are discussed and management strategies for patients on long-term antiplatelet and anticoagulant therapy reviewed. In part I, we review warfarin and the new direct oral anticoagulants. In part II, we review antiplatelet agents and assessment of platelet function and the perioperative management of long-term anticoagulant and antiplatelet therapy.

  • anticoagulation
  • warfarin
  • Oral anticoagulation

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