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Surgeon's guide to anticoagulant and antiplatelet medications part two: antiplatelet agents and perioperative management of long-term anticoagulation
  1. Louise Y Y Yeung1,
  2. Babak Sarani2,
  3. Jordan A Weinberg3,
  4. Paul B McBeth4,
  5. Addison K May5
  1. 1Kaiser Permanente Medical Center, Los Angeles, California, USA
  2. 2Center for Trauma and Critical Care, George Washington University, Washington, District of Columbia, USA
  3. 3Department of Surgery, Dignity Health/St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA
  4. 4Departments of Surgery and Critical Care Medicine, University of Calgary, Calgary, Alberta, Canada
  5. 5Division of Trauma and Surgical Critical Care, Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
  1. Correspondence to Dr Addison K May; addison.may{at}


An increasing number of potent antiplatelet and anticoagulant medications are being used for the long-term management of cardiac, cerebrovascular, and peripheral vascular conditions. Management of these medications in the perioperative and peri-injury settings can be challenging for surgeons, mandating an understanding of these agents and the risks and benefits of various management strategies. In this two part review, agents commonly encountered by surgeons in the perioperative and peri-injury settings are discussed and management strategies for patients on long-term antiplatelet and anticoagulant therapy reviewed. In part one, we review warfarin and the new direct oral anticoagulants. In part two, we review antiplatelet agents and assessment of platelet function and the perioperative management of long-term anticoagulation and antiplatelet therapy.

  • anticoagulation
  • warfarin
  • antiplatelet
  • reversal

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