Shock is the inability of the body to maintain adequate end-organ perfusion. Hypovolemic
shock caused by blood loss is frequently encountered after severe injury. 1 Hemorrhagic …

Abdominal vascular trauma, primarily due to penetrating mechanisms, is uncommon.
However, when it does occur, it can be quite lethal, with mortality ranging from 20% to 60 …

BACKGROUND There is no consensus as to the optimal treatment paradigm for patients
presenting with hemorrhage from severe pelvic fracture. This study was established to …

Conventional wisdom presumes that the α 7nAChR product of CHRNA7 expression
mediates the ability of the vagus nerve to regulate the inflammatory response to injury and …

The enteric nervous system may have an important role in modulating gastrointestinal
barrier response to disease through activation of enteric glia cells. In vitro studies have …

BACKGROUND Standard venous thromboembolism (VTE) prophylaxis with enoxaparin
results in inadequate protection in certain patients, with subtherapeutic plasma anti-Xa …

We have previously shown that vagal nerve stimulation prevents intestinal barrier loss in a
model of severe burn injury in which injury was associated with decreased expression and …

Importance Randomized clinical trials (RCTs) of therapeutic-dose heparin in patients
hospitalized with COVID-19 produced conflicting results, possibly due to heterogeneity of …

Acute lung injury (ALI) is a common cause of morbidity in patients after severe injury due to
dysregulated inflammation, which is believed to be driven by gut‐derived inflammatory …

Methods: Male balb/c mice underwent right cervical vagal nerve stimulation for 10 minutes
immediately before 30% total body surface area, full-thickness steam burn. In a separate …