ABSTRACT A comprehensive understanding of the neurobiology of alcohol cue reactivity is
critical in identifying the neuropathology of alcohol use disorders (AUD) and developing …

Although many alcoholics experience craving, researchers have not yet developed a
common, valid definition of the phenomenon. Numerous models of the mechanisms …

“Craving” for alcohol needs improved definition and measurement. This review provides a
rationale for considering at least certain aspects of craving as having obsessive and …

ContextAlcohol dependence treatment may include medications, behavioral therapies, or
both. It is unknown how combining these treatments may impact their effectiveness …

It has been suggested that a crucial dimension of alcohol “craving” includes the concept of
both obsessive thoughts about alcohol use and compulsive behaviors toward drinking. An …

ContextHypothetically, topiramate can improve drinking outcomes among alcohol-
dependent individuals by reducing alcohol's reinforcing effects through facilitation of γ …

Background: The 14-item Obsessive Compulsive Drinking Scale (OCDS) is a quick and
reliable self-rating instrument that provides a total and two subscale scores that measure …

Using fMRI, our group previously found that after a sip of alcohol and exposure to alcohol
beverage pictures, alcoholics compared to social drinkers had increased differential brain …

Objective: The opiate antagonist drug naltrexone has been shown in a few studies with
limited sample sizes to be effective when combined with psychosocial therapies for the …

Context Naltrexone hydrochloride treatment for alcohol dependence works for some
individuals but not for everyone. Asn40Asp, a functional polymorphism of the μ-opioid …