Routine repeat head CT may not be necessary for patients with mild TBI
Background Routine repeat cranial CT (RHCT) is standard of care for CT-verified traumatic
brain injury (TBI). Despite mixed evidence, those with mild TBI are subject to radiation and …
brain injury (TBI). Despite mixed evidence, those with mild TBI are subject to radiation and …
Chance to cut: defining a negative exploration rate in patients with suspected necrotizing soft tissue infection
EC Howell, JA Keeley, AH Kaji, MR Deane… - Trauma surgery & …, 2019 - tsaco.bmj.com
Background Necrotizing soft tissue infections (NSTI) are aggressive infections associated
with significant morbidity and mortality. Despite multiple predictive models for the …
with significant morbidity and mortality. Despite multiple predictive models for the …
Activity-based exposure comparisons among humans and nonclinical safety testing species in an extensively metabolized drug candidate
X Zhu, JG Slatter, MG Emery, MR Deane, A Akrami… - Xenobiotica, 2013 - Taylor & Francis
Extensive metabolism of a drug candidate can complicate the interpretation of comparative
safety and efficacy data from humans and preclinical species. 2. The 11β-hydroxysteroid …
safety and efficacy data from humans and preclinical species. 2. The 11β-hydroxysteroid …
Regiospecific and stereospecific triangulation of the structures of metabolites formed by sequential metabolism at multiple prochiral centers
RJ Greene, JA Davis, R Subramanian… - Drug Metabolism and …, 2012 - ASPET
Structures of in vivo secondary metabolites of a norbornane-containing drug candidate with
multiple prochiral centers were triangulated, in a regio-and stereospecific fashion, using in …
multiple prochiral centers were triangulated, in a regio-and stereospecific fashion, using in …
Biliary Tract Microflora in Patients Undergoing Cholecystectomy for Acute Biliary Tract Disease: An Analysis of the Effect of Bile Spillage and Microbiology on …
D Beaulieu, K Ojukwu, HKE Kim, T Lee… - Journal of the …, 2022 - journals.lww.com
METHODS: A retrospective chart review was conducted of all patients older than 18 years
undergoing urgent laparoscopic cholecystectomy at an academic hospital from January to …
undergoing urgent laparoscopic cholecystectomy at an academic hospital from January to …
Wound culture utility in negative surgical exploration for necrotizing soft tissue infection
Early surgical intervention decreases mortality in necrotizing soft tissue infections (NSTIs).
Yet, a subset of patients will not have NSTIs (non-NSTIs) at the time of exploration. We …
Yet, a subset of patients will not have NSTIs (non-NSTIs) at the time of exploration. We …
Incarcerated Umbilical and Ventral Hernia Repair
MR Deane, DY Kim - Emergency General Surgery: A Practical Approach, 2019 - Springer
Incarcerated umbilical and ventral hernias require emergent surgical intervention in order to
prevent life-threatening complications including strangulation and bowel perforation. Upon …
prevent life-threatening complications including strangulation and bowel perforation. Upon …
Acute Respiratory Distress Syndrome and Lung Protective Ventilation
SE Greer, RE Duncan, MR Deane, NM Habashi… - Principles of Adult …, 2016 - Springer
Surgical patients are at high risk for development of acute respiratory distress syndrome
(ARDS). While there is vast literature on this topic, there continues to be uncertainty in …
(ARDS). While there is vast literature on this topic, there continues to be uncertainty in …