Methods: The records of all patients admitted to the ICU over a 2-year period at a Level I
trauma center were reviewed for age, injury severity scores (ISS), admission Glasgow Coma …

Objective The authors' objective was to resolve the current controversies surrounding the
diagnosis and management of blunt pancreatic trauma (BPT). Summary Background Data …

Objective: The goal of this report is to examine the success of vacuum-assisted fascial
closure (VAFC) under a carefully applied protocol in abdominal closure after open …

The relative infrequency of blunt carotid artery trauma prompted a multicenter review to
determine the spectrum of injuries, treatment strategies, and neurologic outcome. During a …

Background Bleeding pelvic fractures (BPF) carry mortality as high as 60%, yet controversy
remains over optimal initial management. Some base initial intervention on fracture pattern …

Homeostatic synaptic scaling alters the strength of synapses to compensate for prolonged
changes in network activity and involves both excitatory and inhibitory neurons. The …

Complement pathway overactivation can lead to neuronal damage in various neurological
diseases. Although Alzheimer's disease (AD) is characterized by β-amyloid plaques and tau …

Background Increased intra-abdominal pressure (IAP) is an adverse complication seen in
critically ill, injured, and postoperative patients. IAP is estimated via the measurement of …

Microglia and complement can mediate neurodegeneration in Alzheimer's disease (AD). By
integrative multi-omics analysis, here we show that astrocytic and microglial proteins are …

Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) provides a new tool in
selected patients for the management of non-compressible torso hemorrhage. 1–3 Recent …