Background: Bleeding is the most frequent cause of preventable death after severe injury.
Coagulopathy associated with severe injury complicates the control of bleeding and is …

Improvements in the control of haemorrhage after trauma have resulted in the survival of
many people who would otherwise have died from the initial loss of blood. However, the …

Acute coagulopathy results in increased transfusion requirements, incidence of organ
dysfunction, critical care stay and mortality. Recognition of an early coagulopathic state has …

Injury causes a systemic inflammatory response syndrome (SIRS) that is clinically much like
sepsis. Microbial pathogen-associated molecular patterns (PAMPs) activate innate …

Background: Traumatic coagulopathy is thought to be caused primarily by fluid
administration and hypothermia. Methods: A retrospective study was performed to determine …

Objectives: Coagulopathy following major trauma is conventionally attributed to activation
and consumption of coagulation factors. Recent studies have identified an acute …

Background: Coagulopathy is present at admission in 25% of trauma patients, is associated
with shock and a 5-fold increase in mortality. The coagulopathy has recently been …

Objective: To identify an appropriate diagnostic tool for the early diagnosis of acute traumatic
coagulopathy and validate this modality through prediction of transfusion requirements in …

Rationale: Acute lung injury is a common complication after severe trauma, which
predisposes patients to multiple organ failure. This syndrome largely accounts for the late …

Abstract The American College of Surgeons Committee on Trauma's Advanced Trauma Life
Support Course is currently taught in 50 countries. The 8th edition has been revised …