Background: Death with graft function remains an important cause of graft loss among
kidney transplant recipients (KTRs). Little is known about the trend of specific causes of …

Tumours progress despite being infiltrated by tumour-specific effector T cells. Tumours
contain areas of cellular necrosis, which are associated with poor survival in a variety of …

The COVID‐19 pandemic has significantly changed the landscape of kidney transplantation
in the United States and worldwide. In addition to adversely impacting allograft and patient …

In 2012, Kidney Disease: Improving Global Outcomes (KDIGO) published a guideline on the
classification and management of acute kidney injury (AKI). The guideline was derived from …

The risk of mineral and bone disorders among patients with chronic kidney disease is
substantially elevated, owing largely to alterations in calcium, phosphorus, vitamin D …

T cell antigen receptor (TCR) signaling drives distinct responses depending on the
differentiation state and context of CD8+ T cells. We hypothesized that access of signal …

Catabolic conditions like chronic kidney disease (CKD) cause loss of muscle mass by
unclear mechanisms. In muscle biopsies from CKD patients, we found activated Stat3 (p …

Cancer cells must evade immune responses at distant sites to establish metastases. The
lung is a frequent site for metastasis. We hypothesized that lung-specific immunoregulatory …

Background Acute kidney injury is common, with a major effect on morbidity and health care
utilization. Soluble urokinase plasminogen activator receptor (suPAR) is a signaling …

T cells are central to all currently effective cancer immunotherapies, but the characteristics
defining therapeutically effective anti-tumor T cells have not been comprehensively …