Abstract The World Health Organization (WHO) has declared coronavirus disease 2019
(COVID-19), the disease caused by the severe acute respiratory syndrome coronavirus 2 …

Cryoprecipitate is a diverse product containing factor VIII, von Willebrand factor, fibrinogen,
fibronectin, factor XIII, and platelet microparticles. The role of this complex product in the …

Transfusion-associated graft-versus-host disease (TA-GVHD) is a rare complication of blood
transfusion. The clinicolaboratory features of TA-GVHD and the relative contributions of …

Importance Severely injured patients experiencing hemorrhagic shock often require massive
transfusion. Earlier transfusion with higher blood product ratios (plasma, platelets, and red …

Background—Acute kidney injury (AKI) after cardiac surgery is a major health issue. Lacking
effective therapies, risk factor modification may offer a means of preventing this complication …

The efficacy of convalescent plasma for coronavirus disease 2019 (COVID-19) is unclear.
Although most randomized controlled trials have shown negative results, uncontrolled …

Background Fresh red cells may improve outcomes in critically ill patients by enhancing
oxygen delivery while minimizing the risks of toxic effects from cellular changes and the …

Background: Cardiac surgery is frequently complicated by coagulopathic bleeding that is
difficult to optimally manage using standard hemostatic testing. We hypothesized that point …

Background In the pivotal RESPONSE study, ruxolitinib, a Janus kinase (JAK) 1 and JAK2
inhibitor, was superior to best available therapy at controlling haematocrit and improving …

Importance Traumatic brain injury (TBI) is the leading cause of death and disability due to
trauma. Early administration of tranexamic acid may benefit patients with TBI. Objective To …