Abstract
Against an autobiographic background, a historical sketch is given of the development of the technique of thrombin generation, from subsampling to duly calibrated continuous measurement with fluorogenic substrates. Its application to various problems in the pathophysiology of hemostasis and thrombosis is discussed.
Publication types
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Autobiography
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Biography
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Historical Article
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Portrait
MeSH terms
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Anticoagulants / history
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Anticoagulants / pharmacology
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Blood Platelets / physiology
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Hematology / history*
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Hemostasis / physiology
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Heparin, Low-Molecular-Weight / history
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Heparin, Low-Molecular-Weight / pharmacology
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History, 20th Century
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History, 21st Century
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Humans
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Netherlands
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Prothrombin / metabolism
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Thrombin / biosynthesis
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Thrombin / history*
Substances
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Anticoagulants
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Heparin, Low-Molecular-Weight
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Prothrombin
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Thrombin