Historical Sketch
Recollections on thrombin generation

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Summary

Against an autobiographic background, a historical sketch is given of the development of the technique of thrombin generation, from subsampling to duly calibrated continuous measurement with fluorogenic substrates. Its application to various problems in the pathophysiology of hemostasis and thrombosis is discussed.

Keywords

antithrombotic treatment
heparins
hypercoagulability
memoirs
screening test
thrombin generation

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