Complement and the immune response

doi:10.1016/S0952-7915(97)80160-4

Current Opinion in Immunology

Volume 9, Issue 1, February 1997, Pages 64-69

https://doi.org/10.1016/S0952-7915(97)80160-4 Get rights and content

Abstract

This past year has seen a major advance in our understanding of how the complement system enhances the adaptive immune response. The use of in vivo models has revealed that direct coupling of C3d to antigen is sufficient to dramatically reduce the amount of antigen required for a secondary response. At least one important requirement for the enhancing effect was determined to be expression of the CD21 (C3d receptor) on B cells.

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Complement and the immune response

Abstract

J Exp Med

J Immunol

Molecular organization and function of the complement system

Annu Rev Biochem

The CD19/CD21/TAPA-1 complex of B lymphocytes: linking natural to acquired immunity

Annu Rev Immunol

The follicular dendritic cell: its role in antigen presentation in the generation of immunological memory

Immunol Rev

C3d of complement as a molecular adjuvant: bridging innate and acquired immunity

Science

Natural antibody and complement-mediated antigen processing and presentation by B lymphocytes

J Immunol

C3b covalently associated to tetanus toxin modulates TT processing and presentation by U937 cells

Mol Immunol

Covalent binding of C3b to monoclonal antibodies selectively up-regulates heavy chain recognition by T cells

Eur J Immunol

Modulation of antigen processing and presentation by covalently linked complement C3b fragment

Immunology

IFN-gamma up-regulates expression of complement components C3 and C4 by stabilization of mRNA

J Immunol

Differential expression of complement C3 and C4 in the human kidney

J Clin Invest