These are examples of six major content areas related to clinical trials and example issues that are discussed in the manuscript related to each content area.
| Clinical trial content area | Example issue |
| Funding mechanism | Other transaction authority versus conventional grants (R01) |
| Trial infrastructure | Clinical trials networks |
| Contracting | CTSA program contract language |
| Enrollment | Use of platform trials |
| Expertise | Statistical analysis and planning |
| Publication | Early publication policy |
CTSA, Clinical and Translational Science Awards.