Complications and mortality data
| HYPOFIB (n=18) | NORMAL (n=168) | P value | |
| Acute renal failure | 12.5% | 3.5% | 0.075 |
| Sepsis | 6.3% | 16.7% | 0.249 |
| Venous thromboembolism | 0% | 5% | 0.331 |
| Acute respiratory distress syndrome | 12.5% | 5.6% | 0.250 |
| Hospital-free days | 0 (0, 0) | 11 (0, 21) | <0.001 |
| Ventilator-free days | 0 (0, 0) | 27 (0, 30) | <0.001 |
| ICU-free days | 0 (0, 0) | 22 (0, 28) | <0.001 |
| PaO2/FiO2 at 24 hours | 189 (68, 482) | 415 (270, 522) | 0.040 |
| PaO2/FiO2 at 48 hours | 376 (283, 424) | 382 (291, 482) | 0.565 |
| PaO2/FiO2 at 72 hours | 338 (285, 420) | 360 (255, 450) | 0.862 |
| 24-hour mortality | 19% | 21% | 0.81 |
| 30-day mortality | 82% | 28% | <0.001 |
| Cause of death, TBI | 79% | 62% | 0.083 |
| Cause of death, hemorrhage | 0% | 18% | 0.049 |
| Time to death, hours | 36 (31, 47) | 12 (0.2, 35) | 0.014 |
HYPOFIB, hypofibrinogenemic; ICU, intensive care unit; TBI, traumatic brain injury.