PICO 3 (selective vs non-selective NSAIDs)
| Author | Outcome definition | Groups | N | Male, n (%) | Age, years, mean (SD) | Outcome, n (%) | Study conclusions |
| Non-union | |||||||
| Jeffcoach19 | Not defined | Selective NSAID Non-Selective NSAID | 8 185 | NR NR | NR NR | 0 (0) 7 (3.8) | No statement on selective NSAID use. |
| George4 | Non-union diagnosis code or a procedure to treat non-union | Selective NSAID Non-Selective NSAID | 2 411 22 590 | 11 229 (45) 103 003 (37) | 49 (17) 60 (19) | 69 (2.9) 387 (1.7) | Filling a prescription for a non-selective NSAID after fracture was not associated with an increased risk of non-union in the subsequent year. Both COX-2-inhibitor and opioid prescription fills after fracture were associated with a greater risk of non-union. |
| Pain | |||||||
| Ortiz10 | Pain (VAS) at 24 hours | Ketorolac (non-selective) Diclofenac (non-selective) Etoricoxib (Selectve) | 15 17 17 | NA NA NA | 39 (14) 38 (19) 37 (10) | 25 (24 hours) 25 (24 hours) 25 (24 hours) | All studied NSAIDs were equally effective analgesics. |
NSAID, non-steroidal anti-inflammatory drugs; VAS, visual analog scale.