Table 1

Available literature that discusses the impact of sickle cell trait and trauma

Literature results on SCT with traumaFrequency (%)
Publication date
 On or before 200054 (29%)
 After 2000131 (71%)
Publication type
 Case reports96 (52%)
 Original research58 (31%)
 Other (opinion, editorial)31 (17%)
Publication content+
 Not directly related to SCT and Trauma (incidental mention of SCT or trauma, mental trauma, and so on)150 (81%)
 Unisystem trauma and SCT32 (17%)
 Multisystem trauma and& SCT3 (2%)
 TOTAL directly related to SCT and trauma35 (19%)
Anatomic setting of trauma (N=34)
 Ocular24 (69%)
 Rhabdomyolysis (muscle)4 (11%)
 Renal2 (6%)
 Splenic0 (0%)
 Other (cardiac, bone, thigh GSW, neck)5 (14%)
Physiological characteristics (N=35)
 Acidosis0 (0%)
 Dehydration1 (3%)
 Exertion1 (3%)
 Hypertension1 (3%)
 Hypoxia2 (6%)
 Infarct/myonecrosis0 (0%)
 Procoagulant and endothelial damage (VTE)0 (0%)
 Vaso-occlusion and sickling11 (31%)
  • ‘+’ designation defines articles that reference patients/subjects with sickle cell trait who had sustained trauma or injury to one or multiple body sites and systems (ie, eyes, chest, thigh, and so on). Publications that were directly related to trauma in patients with SCT and subjects include all ranges of publication dates and types except opinion and editorial pieces.

  • SCT, sickle cell trait; VTE, venous thromboembolism.