Baseline and shock characteristics
| Control | ddAVP | |||
| Baseline | Hemorrhagic shock | Baseline | Hemorrhagic shock | |
| Clinical parameters | ||||
| n | 7 | 7 | ||
| Weight (g) | 374 (364–384) | 367 (362–373) | ||
| Temperature (°C) | 36.6 (36.0–37.4) | 37.0 (36.6–37.2) | 36.9 (36.7–37.7) | 36.8 (36.0–37.3) |
| Blood gas | ||||
| pH | 7.46 (7.35–7.50) | 7.36 (7.21–7.39) | 7.39 (7.35–7.43) | 7.33 (7.31–7.44) |
| pCO2 (mm Hg) | 36.1 (30.7–39.4) | 28.1 (19.1–36.5)† | 40.2 (31.9–42.1) | 32.8 (27.4–38.3) |
| HCO3- (mEq/L) | 24 (21–25) | 17 (8–20)† | 24 (23–25) | 18 (17–19)† |
| BD (mmol/L) | 0.7 (−2.9 to 1.3) | −6.4 (−18.2 to 4.3)† | −0.9 (−1.1 to 0.6) | −6.7 (−8.7 to 4.9)† |
| Lactate (mmol/L) | 1.0 (0.6–1.2) | 3.1 (1.9–9.8)† | 0.8 (0.7–1.2) | 4.0 (2.6–4.6)† |
| Hemoglobin level (g/dL) | 13.7 (13.2–14.7) | 11.0 (10.4–11.9)† | 15.5 (15.1–16.3) | 11.9 (11.6–12.4)† |
| Hemodynamics | ||||
| MAP (mm Hg) | 132 (124–144) | 42 (32–53)† | 150 (144–158)* | 41 (37–47)† |
| Heart rate (bpm) | 280 (260–300) | 280 (208–308) | 280 (260–290) | 250 (230–270) |
| Volume bled (mL) | NA | 8.0 (8.0–9.0) | NA | 9.0 (8.0–10.0) |
| Estimated blood volume (mL) | NA | 21 (21–22) | NA | 21 (21–21) |
| % of estimated total blood volume bled | NA | 38 (35–42) | NA | 44 (39–48) |
Values are presented as median and IQR.
Estimated total blood volume (mL)=0.057 × rat weight in grams.
*Significantly different from control.
†Significantly different from baseline.
BE, base excess; MAP, mean arterial pressure; NA, not applicable; ND, not done.