Comparison of patients according to whether they received empiric antifungal (AF) therapy or not
| Total (n=554) | Empiric AF (n=239) | No empiric AF (n=315) | P value | |
| Age (year), mean±SD (median) | 56.7±17.8 (57.0) | 56.8±18.4 (58.0) | 56.6±17.3 (57.0) | 0.909 |
| Male | 60.5% (335/554) | 59.8% (143/239) | 61.0% (192/315) | 0.789 |
| CCI, mean±SD (median) | 4.0±3.7 (3.0) | 4.1±3.5 (3.0) | 4.0±3.9 (3.0) | 0.744 |
| Previous PUD | 23.7% (131/553) | 25.1% (60/239) | 22.6% (71/314) | 0.495 |
| Steroid use | 9.4% (52/553) | 11.7% (28/239) | 7.6% (24/314) | 0.104 |
| PPI use | 18.1% (100/553) | 20.9% (50/239) | 15.9% (50/314) | 0.130 |
| Pneumoperitoneum | 94.9% (525/553) | 97.1% (231/238) | 93.3% (294/315) | 0.048 |
| Fever >38 C | 4.4% (24/546) | 5.5% (13/237) | 3.6% (11/309) | 0.277 |
| Laparoscopic approach | 23.5% (130/554) | 23.4% (56/239) | 23.5% (74/315) | 0.751 |
| Surgery type | ||||
| Omental patch | 78.3% (434/554) | 79.5% (190/239) | 77.5% (244/315) | 0.843 |
| Gastrectomy | 4.5% (25/554) | 4.2% (10/239) | 4.8% (15/315) | |
| Other | 17.1% (95/554) | 16.3% (39/239) | 17.8% (56/315) | |
| Surgical drain at index surgery | 51.9% (287/553) | 56.5% (135/239) | 48.4% (152/314) | 0.060 |
| Blood cultures at admission (+) for Candida spp | 7.9% (13/164) | 6.8% (6/88) | 9.2% (7/76) | 0.572 |
| IP cultures obtained at index surgery | 31.9% (177/554) | 39.7% (95/239) | 26.0% (82/315) | 0.001 |
| IP cultures (+) for Candida spp | 42.9% (76/177) | 46.3% (44/95) | 39.0% (32/82) | 0.328 |
P values were obtained from t-test or Mann-Whitney test for continuous variables, and from χ2 or Fisher’s exact test for dichotomous variables.
CCI, Charlson Comorbidity Index; IP, intraperitoneal; PPI, proton pump inhibitor; PUD, peptic ulcer disease.