Table 1

GO biologic processes significantly enriched after valproic acid treatment delivered intraosseously

GO termP value
Heart
 Positive regulation of molecular function0.005
 Regulation of catalytic activity0.006
 Inflammatory response0.007
 Regulation of hydrolase activity0.012
 Positive regulation of protein metabolism0.018
Lung
 NF-kB inducing kinase (NIK)/neutrophil factor-kappa beta (NF-kB) signaling5×10–5
 Negative regulation of macromolecule metabolic process2×10–4
 mRNA catabolic process2×10–4
 Cellular macromolecule biosynthetic process2.8×10–4
 Negative regulation of gene expression4.1×10–4
 Regulation of canonical Wnt signaling pathway5.3×10–4
 Animal organ morphogenesis5.4×10–4
 Skp, cullin, F- box containing complex (SCF)-dependent proteasomal ubiquitin-dependent protein catabolic process5.4×10–4
 Regulation of hematopoeietic stem cell differentiation6.3×10–4
 Anaphase promoting complex7.3×10–4
Liver0.037
 Positive regulation of molecular function0.005
 Regulation of catalytic activity0.006
 Inflammatory response0.007
 Regulation of hydrolase activity0.024
 Positive regulation of protein metabolism0.042

  • For lung, only the 10 most significantly enriched biologic processes are shown, as 189 biologic processes were enriched.

  • GO, gene ontology.