Patient and injury characteristics—subgroup (Injury Severity Score >30, n=127)
| Variable | Plasma group | P value | |
| YOUNG | OLD | ||
| Demographics | n=30 | n=34 | |
| Age, years, mean (SD) | 40.0 (14.8) | 41.9 (19.4) | 0.65 |
| Male gender, No. (%) | 18 (60) | 23 (68) | 0.52 |
| Race, No. (%) | 0.15 | ||
| White | 29 (97) | 29 (85) | |
| Black | 0 (0) | 4 (12) | |
| Unknown | 1 (3) | 1 (3) | |
| Hispanic, No. (%) | 0 (0.0) | 0 (0.0) | 0.34 |
| Current smoking, No. (%) | 13 (59) | 13 (54) | 0.74 |
| Body mass index, mean (SD) | 30.2 (9.8) | 29.6 (7.4) | 0.84 |
| Prehospital and injury | |||
| Penetrating injury, No. (%) | 4 (13) | 3 (9) | 0.56 |
| Injury severity score, median (IQR) | 43.0 (35.0, 50.0) | 41.0 (34.0, 45.0) | 0.26 |
| Traumatic brain injury, No. (%) | 8 (50.0) | 7 (58.3) | 0.66 |
| Admission heart rate, mean (SD) | 112.5 (29.6) | 98.9 (34.1) | 0.10 |
| Admission systolic blood pressure, mean (SD)) | 91.8 (33.1) | 94.3 (51.4) | 0.83 |
| Hospital transfer, No. (%) | 6 (20.0) | 7 (21.2) | 0.47 |
| Prehospital interval, median (IQR) | 41.5 (32.8, 54.6) | 40.4 (32.8, 48.1) | 0.48 |
| Hospital | |||
| Admission INR, median (IQR) | 1.2 (1.1, 1.5) | 1.2 (1.1, 1.3) | 0.72 |
| Admission hemoglobin, median (IQR) | 11.2 (10.3, 12.6) | 10.2 (8.9, 11.4) | 0.084 |
| Admission rapid thromboelastography | |||
| Lysis at 30 min, %, median (IQR) | 0.2 (0.0, 0.9) | 0.2 (0.0, 2.5) | 0.85 |
| Max amplitude, min, median (IQR) | 59.6 (53.0, 61.5) | 55.0 (49.1, 60.6) | 0.42 |
| Alpha angle, degrees, median (IQR) | 70.0 (68.5, 73.9) | 68.2 (61.9, 74.2) | 0.79 |
| K-time, min, median (IQR) | 1.8 (1.4, 1.8) | 2.0 (1.5, 2.7) | 0.65 |
| Activated clotting time, median (IQR) | 117.0 (109.0, 124.5) | 113.0 (89.0, 136.0) | 0.64 |
| PRBC in 24 hours, median (IQR) | 4.0 (2.0, 11.0) | 4.5 (2.0, 10.0) | 0.90 |
| Plasma in 24 hours, median (IQR) | 2.0 (0.0, 4.0) | 0.5 (0.0, 4.0) | 0.95 |
| Platelets in 24 hours, median (IQR) | 0.0 (0.0, 1.0) | 0.0 (0.0, 1.0) | 0.78 |
| Crystalloid in 24 hours, median (IQR) | 5110.0 (3200.0, 6647.0) | 4437.5 (1500.0, 7050.0) | 0.49 |
| Multisystem organ failure, No. (%) | 20 (66.7) | 25 (73.5) | 0.55 |
INR, international ratio; No., number; PRBC, packed red blood cells.