Table 1

Review of the literature regarding coagulopathy and outcomes among sepsis survivors

Senior authorYearDesignnInclusionParameter(s)Sampling timingPrimary outcomeConclusion
Nelson DR242005Prospective840Severe sepsisPT, AT, D-dimer, APC, SOFADiagnosis28-day mortalityCoagulopathy the first day after diagnosis predicts worse 28-day mortality.
Angus DC672011Multicenter cohort893Community Acquired PneumoniaAT, factor IX, TAT, PAI-1, D-dimerAdmission, weekly until dischargeAll-cause, cardiovascular,
1-year mortality
Elevated TAT and D-dimer within 96 hours of discharge predict cardiovascular death.
Gothot A422012Prospective cohort39Septic shock17 coagulopathy markersAdmission through day 7Inpatient, 90-day mortalityThrombin generation deficit is associated with greater 90-day mortality.
Jones AE642014Systematic reviewDIC/coagulopathy>28 daysOrgan-specific outcomesVariable rates of coagulopathy and resolution 1 month after severe sepsis.
Sakata Y662014Prospective37Sepsis without DIC at baseline14 coagulopathy markersAdmissionDIC development,
28-day mortality
TAT and PAI-1 predict 28-day mortality.
Jones AE652016Retrospective110Severe sepsis/shockINR >1.5
Platelets <100 000/µL
Admission, 28–90 days, and >90 daysOrgan dysfunctionINR >1.5 is associated with organ dysfunction at 28–90 days.
Mebazaa A722018Multicenter prospective1570Critical illness ICU survivorsPlatelets <100 000/µLDischargeAll-cause 1-year mortalityLow platelets at discharge are associated with greater risk 1-year mortality.
  • APC, activated protein C; DIC, disseminated intravascular coagulopathy; ICU, intensive care unit; INR, international normalized ratio; PAI-1, plasminogen activator inhibitor-1; PT, prothrombin time; SOFA, Sequential Organ Failure Assessment; TAT, thrombin-antithrombin complex.