Table 3

Mortality and morbidity in patients with and without ATC defined by an INR ≥1.3.

ATC (n=88)No ATC (n=457)
Complication and event outcomes% (95% CI)% (95% CI)p value
Development of new or progressive MODS64.8 (54.8 to 74.8)7.7 (5.2 to 10.1)<0.001
In-hospital mortality26.1 (17.6 to 36.5)0.4 (0 to 1)<0.001
Developed of PARDS35.2 (25.1 to 45.5)3.5 (1.8 to 5.2)<0.001
Readmission within 30 days of discharge1.2 (1.1 to 3.5)1.3 (0.3 to 2.4)0.92
Duration outcomesMedian days (IQR)Median days (IQR)p value
Duration of hospitalization in survivors10 (7.7 to 12.3)3 (2.8 to 3.2)<0.001
PICU-free days at day 2817 (0 to 23)26 (25 to 28)<0.001
Mechanical ventilator-free days at day 2821 (0 to 27)28 (28 to 28)<0.001
  • New or progressive MODS was defined by the Proulx et al criteria and excludes hematologic dysfunction.22 25 26 PARDS was defined by the pediatric acute lung injury consensus conference definition.27 The total number of survivors in patients with ATC and without ATC was 63 and 455, respectively. Those that died were considered to have 0 PICU-free days and 0 mechanical ventilator-free days at day 28.

  • ATC, acute traumatic coagulopathy; INR, international normalized ratio; IQR, interquartile range; MODS, multiple organ dysfunction syndrome; PARDS, pediatric acute respiratory distress syndrome; PICU, pediatric intensive care unit.