Patient demographics at presentation and their respective SVRi/LCWi at T0 and T1
| Patient | Age, sex | Medical history | Final diagnosis | Culture* | Alert criteria† | T0 | T1 | ||
| SVRi (dyne*s/cm5/m²) | LCWi (kg*m/m²) | SVRi (dyne*s/cm5/m²) | LCWi (kg*m/m²) | ||||||
| 1 | 77, male | DM, Htn, CKD | Soft tissue infection | Pseudomonas in foot wound | HR (120), WCC (1.1), bands (16%), SBP (70), MAP (50), Lac (4.0) | 1565 | 2.4 | 1740 | 2.5 |
| 2 | 77, male | COPD, Htn, CAD | Pneumonia on CXR | None | Temp (38.7), HR (120), WCC (15.2), Lac (3.5) | 2095 | 2.1 | 2436 | 5.0 |
| 3 | 46, female | None | Urosepsis | Citrobacter in urine and blood | HR (120), temp (40.2), WCC (13.9), INR (1.6)‡ | 1539 | 4.8 | 2166 | 4.1 |
| 4 | 42, male | None | Sulfa-induced hepatitis | None | Temp (40.3), HR (99), RR (22), WCC (2.5), platelets (82) | 1990 | 2.7 | 2081 | 4.4 |
| 5 | 42, male | CKD, Htn | Soft tissue infection | None | Temp (38.3), WCC (22.4), SBP (76), MAP (51), Cr (7.32) | 2035 | 4.0 | 2543 | 1.5 |
| 6 | 79, male | CKD, CAD | Pneumonia on CXR | None | RR (28), WCC (14), Cr (2.6), Lac (2.2) | 2281 | 3.8 | 2420 | 3.3 |
| 7 | 33, male | None | Urosepsis | Proteus in urine | HR (136), temp (40.1), bands (16%), WCC (21.5), Lac (3.5) | 1781 | 4.3 | 1445 | 5.4 |
| 8 | 68, female | Htn, DM, Hld | Soft tissue infection | Coagulase (−) staphylococci in blood | Temp (38.7), HR (127), RR (22), WCC (12.5), INR (1.6)‡ | 1541 | 7.2 | 3307 | 3.5 |
| 9 | 44, male | None | Liver abscess | Group C streptococci and Escherichiacoli in abscess | Temp (38.6), HR (115), WCC (16.6), Cr (3.19) | 1559 | 5.2 | 2411 | 4.4 |
*Cultures either not obtained or with negative result listed as “none”.
†Alert criteria defined as two or more SIRS criteria in addition to one organ dysfunction variable: SIRS criteria: temperature >38°C or <36°C, heart rate >90 beats per minute, respiratory rate >20 breaths per minute, white cell count <4x109/L or >12x109/L, >10% bandemia. Organ dysfunction variables: systolic blood pressure <90 mm Hg, mean arterial pressure <65 mm Hg, systolic blood pressure drop >40% of known baseline, bilirubin/creatinine >2mg/dl, or lactate >2meq/L, platelets <100x109/L, INR >1.5 or activated partial thromboplastin time >60 seconds.
‡Patients with an elevated INR were not factitiously prolonged due to the effects of coumadin.
Bands, bandemia; CAD, coronary artery disease; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; Cr, creatinine; CXR, chest X-ray; DM, diabetes mellitus; Hld, hyperlipidemia; HR, heart rate; Htn, hypertension; INR, international normalized ratio; Lac, lactate; LCWi, left cardiac work index; MAP, mean arterial pressure; RR, respiratory rate; SBP, systolic blood pressure; SIRS, systemic inflammatory response syndrome; SVRi, systemic vascular resistance index; T0, time prebolus; T1, time + 1 hour postbolus; Temp, temperature; WCC, white cell count.