Panel of systemic and lung proinflammatory and anti-inflammatory, endothelial and coagulation biomarkers
| Biomarkers | All patients (n=147) | No MODS (n=115) | MODS (n=32) |
| MPO (ng/mL) | 29.3 (20.2–44.7) | 25.8 (18.2–41.7) | 35.7 (26.2–58.8)** |
| TNF-α (pg/mL) | 6.9 (1.7–13.4) | 7.9 (1.7–13.2) | 1.7 (1.7–14.6) |
| TNF-RI (pg/mL) | 1766.4 (1292.4–2460.4) | 1627.1 (1218.0–2288.7) | 2280.1 (1631.9–3427.1)** |
| TNF-RII (pg/mL) | 1665.0 (1226.8–2340.3) | 1628.3 (1203.4–2309.7) | 1841.1 (1314.4–3058.9) |
| IL-6 (pg/mL) | 23.2 (13.6–60.4) | 21.8 (11.2–45.5) | 39.8 (21.4–108.2)** |
| IL-8 (pg/mL) | 8.9 (5.8–15.6) | 8.5 (5.4–13.0) | 11.6 (8.0–24.8)** |
| RAGE (pg/mL) | 1844.4 (1242.5–3423.0) | 1670.3 (1151.3–3408.9) | 2302.2 (1677.8–3439.9)* |
| FAS ligand (pg/mL) | 54.7 (36.0–68.9) | 51.5 (31.6–67.3) | 58.1 (48.5–83.3)* |
| SP-D (ng/mL) | 9.1 (5.8–13.4) | 9.3 (6.5–13.1) | 7.2 (5.2–14.0) |
| KL-6 (pg/mL) | 18.9 (10.7–26.6) | 19.3 (11.0–27.0) | 17.2 (10.4–25.6) |
| IL-1RA (pg/mL) | 861.8 (603.3–1394.4) | 774.6 (569.9–1277.7) | 1284.6 (777.2–2911.2)*** |
| IL-10 (pg/mL) | 19.4 (0.8–48.7) | 18.9 (0.8–46.6) | 32.7 (0.8–50.3) |
| MIF-1α (pg/mL) | 228.5 (143.7–266.4) | 228.5 (141.8–264.4) | 233.2 (158.0–288.9) |
| CC-16 (ng/mL) | 14.0 (8.0–25.7) | 12.3 (7.4–21.4) | 25.0 (14.1–44.1)*** |
| E-selectin (ng/mL) | 16.6 (12.9–22.2) | 17.5 (13.0–22.8) | 16.2 (11.1–19.5) |
| TF (pg/mL) | 30.7 (24.1–37.8) | 30.5 (24.1–37.8) | 31.3 (23.9–38.2) |
| ICAM-1 (ng/mL) | 225.1 (162.4–324.8) | 233.4 (162.4–324.8) | 206.9 (159.5–336.1) |
| VCAM-1 (ng/mL) | 769.1 (571.9–984.6) | 769.1 (578.0–992.3) | 776.8 (558.9–939.0) |
| PAI-1 (ng/mL) | 3.8 (0.8–26.4) | 3.7 (0.8–25.0) | 9.5 (0.7–31.7) |
Data are represented as median with IQR. Comparisons are made between patients with and without MODS.
*p<0.05; **p<0.01; ***p<0.001.
CC-16, Clara cell protein 16; FAS, first apoptosis signal; ICAM-1, intercellular adhesion molecule 1; IL, interleukin; IL-1RA, interleukin 1 receptor antagonist; KL-6, Krebs von den Lungen-6; MIF-1α, macrophage migration inhibitory factor-1α; MODS, multiple organ dysfunction syndrome; MPO, myeloperoxidase; PAI-1, plasminogen antigen inhibitor 1; RAGE, receptor for advanced glycation end-products; SP-D, surfactant protein D; TF, tissue factor; TNF-α, tumor necrosis factor-α; TNF RI (CD120a), tumor necrosis factor-α receptor I; TNF RII (CD120b), tumor necrosis factor-α receptor II; VCAM-1, vascular cell adhesion molecule 1.