Timepoint | |||
Variable | Group | Baseline | End of shock |
Weight (g) | Vehicle | 272.±11.4 | – |
MC1568 | 276.3±7.4 | – | |
ACY1083 | 279.5±10.0 | ||
MC1568+ACY1083 | 270.5±11.7 | ||
VPA | 278.0±8.3 | ||
Cannulation time (min) | Vehicle | 13.3±1.7 | – |
MC1568 | 15.0±1.6 | ||
ACY1083 | 15.5±2.3 | – | |
MC1568+ACY1083 | 18.5±1.0 | ||
VPA | 13.5±1.5 | ||
MAP (mm Hg) | Vehicle | 94.9±1.5 | 50.8±3.5* |
MC1568 | 92.2±5.4 | 49.1±1.3* | |
ACY1083 | 92.7±7.2 | 53.7±4.2* | |
MC1568+ACY1083 | 93.3±4.4 | 53.8±2.3* | |
VPA | 94.1±4.5 | 57.9±2.9* | |
Lactate (mmol/L) | Vehicle | 1.4±0.1 | 4.3±1.0* |
MC1568 | 1.5±0.2 | 4.9±0.6* | |
ACY1083 | 1.3±0.1 | 4.7±0.5* | |
MC1568+ACY1083 | 1.2±0.1 | 4.5±0.3* | |
VPA | 1.3±0.2 | 4.3±0.6* |
*Significant difference compared with the baseline value of the same group (p<0.05).
MAP, mean arterial pressure; VPA, valproic acid.