Demographic and clinical data
| Variable | All patients | NSTI | Non-NSTI | P value |
| n=295 | n=232 | n=63 | ||
| Sex, n (%) | ||||
| Female | 76 (25.8) | 56 (24.1) | 20 (31.7) | 0.2 |
| Male | 219 (74.2) | 176 (75.9) | 43 (68.3) | |
| Age, median (IQR) years | 50 (41–56) | 50 (42–56) | 50 (37–60) | 0.8 |
| Comorbidity, n (%) | ||||
| Diabetes mellitus | 172 (58.3) | 153 (65.9) | 19 (30.2) | <0.0001 |
| Congestive heart failure | 18 (6.1) | 14 (6.0) | 4 (6.3) | 1.0 |
| Intravenous drug use | 18 (6.1) | 14 (6.0) | 4 (6.3) | 1.0 |
| Cirrhosis | 17 (5.8) | 13 (5.6) | 4 (6.3) | 0.8 |
| Steroids | 12 (4.4) | 9 (3.9) | 3 (4.8) | 0.7 |
| HIV | 5 (1.7) | 4 (1.7) | 1 (1.6) | 1.0 |
| Chemotherapy | 2 (0.7) | 1 (0.4) | 1 (1.6) | 0.4 |
| Location of soft tissue infection, n (%) | ||||
| Upper extremity | 28 (9.5) | 20 (8.6) | 8 (12.7) | 0.3 |
| Lower extremity | 183 (62.0) | 133 (57.3) | 50 (79.4) | 0.001 |
| Pelvic, perineal, perianal | 72 (24.4) | 67 (28.9) | 5 (7.9) | 0.0004 |
| Trunk | 26 (8.8) | 23 (9.9) | 3 (4.8) | 0.3 |
| Duration of symptoms, median (IQR) days | 4 (3–7) | 5 (3–7) | 3 (1–7) | 0.004 |
| Vitals, median (IQR) | ||||
| Temperature (°C) | 37.2 (36.7-38.1) | 37.2 (36.7-38.1) | 37.3 (36.9-38.1) | 0.2 |
| Heart rate | 101 (91–114) | 101 (91–115) | 100 (88–109) | 0.3 |
| Respiration rate | 18 (17–20) | 18 (17–20) | 20 (18–21) | 0.4 |
| Physical examination, n (%) | ||||
| Bullae | 55 (18.6) | 40 (17.2) | 15 (23.8) | 0.3 |
| Violaceous | 36 (12.4) | 21 (9.1) | 15 (23.8) | 0.004 |
| Crepitus | 37 (12.5) | 35 (15.1) | 2 (3.2) | 0.009 |
| Illness severity, n (%) | ||||
| Septic shock | 44, (15.3) | 35, (15.6) | 9, (14.3) | 1.0 |
NSTI, necrotizing soft tissue infection.