Total | GAS necrotizing fasciitis | Non-GAS necrotizing fasciitis | P value | |
n=81 (100%) | n=38 (47%) | n=43 (53%) | ||
Age (median, IQR) | 56 (27) | 50 (29) | 61 (20) | 0.023 |
Sex | ||||
Male | 55 (68%) | 25 (66%) | 30 (70%) | 0.702 |
Female | 26 (32%) | 13 (34%) | 13 (30%) | |
ASA classification | 0.017 | |||
I | 23 (28%) | 17 (45%) | 6 (14%) | |
II | 36 (45%) | 13 (34%) | 23 (53%) | |
III | 14 (17%) | 6 (16%) | 8 (19%) | |
IV | 8 (10%) | 2 (5%) | 6 (14%) | |
Comorbidities* | ||||
Diabetes mellitus | 26 (33%) | 8 (21%) | 18 (42%) | 0.038 |
Cardiovascular disease | 15 (19%) | 6 (16%) | 9 (21%) | 0.519 |
Pulmonary disease | 9 (11%) | 5 (13%) | 4 (10%) | 0.729 |
Medical history* | ||||
Malignancy | 15 (19%) | 7 (18%) | 8 (19%) | 0.943 |
Autoimmune disease | 12 (15%) | 6 (6%) | 6 (6%) | 0.851 |
Surgery within 30 days | 17 (21%) | 7 (18%) | 10 (24%) | 0.556 |
Localization necrotizing fasciitis† | ||||
Abdomen | 5 (6%) | 2 (5%) | 3 (7%) | 1 |
Chest and axilla | 9 (12%) | 8 (21%) | 1 (3%) | 0.013 |
Head and neck | 4 (5%) | 4 (11%) | 0 (0%) | 0.052 |
Extremity | 37 (48%) | 17 (45%) | 20 (50%) | 0.642 |
Perineum | 23 (29%) | 7 (18%) | 16 (40%) | 0.037 |
Time between first presentation and surgery‡ | 0.414 | |||
<12 hours | 42 (60%) | 21 (62%) | 21 (58%) | |
12–24 hours | 8 (11%) | 5 (15%) | 3 (8%) | |
24–48 hours | 14 (20%) | 7 (20%) | 7 (20%) | |
>48 hours | 6 (9%) | 1 (3%) | 5 (14%) |
Bold font denotes significant p value.
*1 (1%) missing case.
†3 (4%) missing cases.
‡11 (14%) missing cases.
ASA, American Society of Anesthesiologists; GAS, Group A Streptococcus.