Laboratory measures of coagulation after attempted reversal
| Dabigatran | Rivaroxaban | Apixaban | P values | |
| Patients reversed (n) | 7 | 31 | 6 | |
| Best INR (IQR)* | 1.3 (1.2–1.4) | 1.2 (1.1–1.3) | 1.1 (1–1.2) | 0.0096 |
| Best aPTT (IQR)† | 34 (29.8–44.6) | 30.1 (26.9–24.5) | 29.2 (26.1–33.2) | 0.0014 |
| Best TEG R median (IQR)‡ | 5.2 (3.9–6.9) | 5.4 (4.3–7.3) | 4.2 (2.4–5) | 0.2125 |
| Best TEG alpha median (IQR)‡ | 70 (67.8–73.6) | 71.2 (65.6–77.4) | 71.2 (63–77) | 0.8723 |
| Best TEG MA median (IQR)‡ | 66.8 (61.5–70.1) | 67.1 (62.4–72.5) | 65.3 (56.7–69.8) | 0.9364 |
Significant values in bold. Normal values: PT=9.7–12.5; aPTT=25–34; R=5–10; alpha=53–72; MA=50–70; lysis=0%–8%.
*Repeat INR performed after reversal in 6 dabigatran, 27 rivaroxaban, and 4 apixaban patients.
†Repeat aPTT performed after reversal in 6 dabigatran, 24 rivaroxaban, and 3 apixaban patients.
‡Repeat TEG performed after reversal in 3 dabigatran, 11 rivaroxaban, and 2 apixaban patients.
INR, international normalized ratio; MA, maximum amplitude; PT, prothrombin time; TEG, thromboelastography; aPTT, activated partial thromboplastin time.