Table 1

Treatment strategies 1 and 2

Treatment strategy 1Treatment strategy 2
Central prostaglandin inhibitor

  • Acetaminophen 1g intravenously/orally every 6 hours × 24 hours.

  • Acetaminophen 1g orally every 6 hours thereafter.

  • Acetaminophen 1g orally every 6 hours.

NSAID COX inhibitor

  • Ketorolac 30 mg intravenously × 1 in ED.

  • Celecoxib 200 mg orally every 6 hours × 48 hours.

  • Naproxen 500 mg orally every 12 hours thereafter.

  • Ketorolac 30 mg intravenously × 1 in ED.

  • Naproxen 500 mg orally every 12 hours.

Weak mu-opioid agonist

  • Tramadol 100 mg orally every 6 hours.

None.
Gabapentinoid

  • Pregabalin 100 mg orally every 8 hours × 48 hours.

  • Gabapentin 300 mg orally every 8 hours thereafter.

  • Gabapentin 300 mg orally every 8 hours thereafter.

Local anesthetics

  • Lidocaine patch every 12 hours.

  • Lidocaine patch every 12 hours.

As needed medications for breakthrough pain (prn medications)

  • Opioids.

  • Tramadol.

  • Opioids.