Patient characteristics by patient cohort
| VALID cohort | ACIT cohort | Gender study cohort | |||||||
| ARDS (n=78) | No ARDS (n=315) | p | ARDS (n=75) | No ARDS (n=119) | p | ARDS (n=105) | No ARDS (n=85) | p | |
| Age (years) | 42 (26–55) | 41 (27–55) | 0.79 | 41 (27–59) | 40 (27–60) | 0.93 | 39 (25–53) | 33 (23–47) | 0.18 |
| Female | 22 (17) | 27 (85) | 0.35 | 16 (12) | 29 (356) | 0.03 | 34 (36) | 29 (25) | 0.50 |
| Caucasian | 78 (61) | 80 (252) | 0.94 | 73 (55) | 63 (75) | 0.14 | 83 (87) | 84 (71) | 0.31 |
| Blunt trauma | 86 (67) | 84 (263) | 0.73 | 100 (75) | 100 (119) | NA | 85 (88) | 86 (72) | 0.96 |
| TBI | 50 (39) | 58 (182) | 0.25 | 75 (56) | 71 (84) | 0.53 | 36 (37) | 51 (43) | 0.036 |
| Arterial base deficit (mEq/L) | 8.8±5.0 | 6.0±5.1 | <0.001 | 6.8±6.5 | 4.0±4.9 | 0.007 | 7.2±5.8 | 4.6±4.2 | <0.001 |
| PaO2/FiO2 | 143 (103–190) | 251 (164–337) | <0.001 | 244 (143–380) | 349 (212–454) | 0.003 | 72 (38–140) | 123 (89–153) | <0.001 |
| ISS | 33 (26–38) | 26 (18–34) | <0.001 | 30 (26–43) | 26 (14–30) | <0.001 | 34 (25–41) | 29 (17–35) | 0.002 |
| APACHE II | 27 (22–31) | 22 (18–27) | <0.001 | 16 (12–20) | 17 (8–23) | 0.84 | 17 (14–21) | 13 (11–17) | <0.001 |
| Vent days (to 28 days) | 10 (4–15) | 4 (2–9) | <0.001 | 11 (7–21) | 3 (2–8) | <0.001 | 9 (5–14) | 4 (3–7) | <0.001 |
| Hospital mortality | 10 (8) | 9 (29) | 0.78 | 36 (27) | 14 (17) | <0.001 | 14 (15) | 5 (4) | 0.03 |
| Ang-2 (pg/mL) | 5880 (4429–7724) | 4007 (2763–5816) | <0.001 | 6812 (4323–12223) | 4393 (3093–6378) | <0.001 | 8681 (5724–14044) | 5697 (3784–8521) | <0.001 |
| RAGE (pg/mL) | 1886 (956–3298) | 944 (646–1523) | <0.001 | 1184 (847–2068) | 912 (588–1348) | <0.001 | 2505 (1779–5081) | 1415 (1024–2022) | <0.001 |
Data as mean±SD, median (IQR) or percentage (number).
ACIT, Activation of Coagulation and Inflammation in Trauma; Ang-2, angiopoietin-2; APACHE II, Acute Physiology and Chronic Health Evaluation II; FiO2, fractional inspired oxygen; ISS, injury severity score; ARDS, acute respiratory distress syndrome; NA, not available; PaO2, arterial oxygen tension (or pressure); RAGE, receptor for advanced glycation endproducts; TBI, traumatic brain injury, defined as AIS head ≥3; VALID, Validating Acute Lung Injury biomarkers for Diagnosis.