Table 2

Biochemical variables in the various groups at the various time points evaluated in the various groups at the various time points evaluated

Serum	Period
Group	Baseline	Shock30	T30	T60	T120
Na (mEq/L)
Sham	145±3.1	149±5.9	144±4.7	154±9.2	135±10.50
Shock-only	138±1.2	141±5.3	140±5.7	132±4.3^b	154±0.00
Shock+LRS	136±2.1	132±1.8^a	131±2.2	131±1.2^c	130±4.70
Shock+Terli	138±2.4	134±2.9^a	138±2.7	134±1.5^c	127±2.90
K (mEq/L)
Sham	4.6±0.3	4.7±0.2	4.6±0.2	5.1±0.3	4.8±0.10
Shock-only	4.8±0.2	5.9±0.4^a	6.4±0.5^b	6.0±0.9	7.7±0.00
Shock+LRS	4.2±0.1	6.4±0.4^a	4.5±0.2^f	5.1±0.1	5.9±0.30
Shock+Terli	4.3±0.1	5.3±0.2^g	5.4±0.2^d	5.4±0.2	5.6±0.40
Cl (mEq/L)
Sham	108±2.1	111±4.6	109±4.4	115±7.7	104±15.5
Shock-only	105±2.4	107±4.3	106±4.7	107±5.2	117±0.0
Shock+LRS	100±1.6	100±1.7	94±4.7	99±1.0^a	94±4.60
Shock+Terli	104±2.2	99±2.2	102±2.1	96±3.1^b	91±3.20
Mg (mg/dL)
Sham	1.9±0.14	1.7±0.10	1.7±0.10	1.7±0.14	1.8±0.10
Shock-only	1.8±0.08	2.1±0.08	2.2±0.11^a	2.1±0.17	2.8±0.00
Shock+LRS	1.8±0.10	2.3±0.13	1.5±0.08^f	1.5±0.09^d	1.7±0.12
Shock+Terli	1.9±0.07	2.1±0.12	1.9±0.09^h	2.1±0.10^h	2.0±0.22
P (mg/dL)
Sham	9.3±1.00	9.4±0.91	9.7±0.74	9.9±0.91	10±2.00
Shock-only	8.8±0.52	10.6±0.59	12.2±0.91^a	10.7±1.00	13±0.00
Shock+LRS	9.3±0.48	12.2±0.85	8.1±0.42^f	8.3±0.51	9.7±0.90
Shock+Terli	8.5±0.40	10.1±0.56	10.8±0.47^d	12.0±0.55^h	11.6±1.8
Urea (mg/dL)
Sham	20.2±2.33	21.8±2.31	23.1±2.93	23.5±2.56	17.0±2.00
Shock-only	20.4±2.33	25.4±2.45	27.4±2.25	24.0±0.45	31.0±0.00
Shock+LRS	19.1±2.01	25.0±2.43	21.3±2.01	33.6±11.46	26.0±4.00
Shock+Terli	26.5±2.76	33.0±3.10	35.1±3.22^a,h	37.2±3.20	41.1±5.10

Urine	Period
Group	Baseline	Shock30	T30	T60	T120
UNaV (mEq/period)
Sham	0.5±0.1	1.2±0.7	0.6±0.3	0.6±0.2	0.8±0.3
Shock-only	0.7±0.1	0.6±0.3	0.2±0.1	0.2±0.1	0
Shock+LRS	0.4±0.1	0.4±0.2	20.5±4.7^c,e	2.2±0.8	0.1±0.0
Shock+Terli	0.5±0.1	0.2±0.1	0.2±0.0ⁱ	0.5±0.3	0.3±0.1
UKV (mEq/period)
Sham	1.8±0.5	4.5±1.4	2.7±0.8	2.7±0.5	2.6±1.7
Shock-only	3.7±1.1	1.5±0.4^a	0.2±0.1	0.1±0.0^a	0
Shock+LRS	1.9±0.3	1.8±0.3^a	12.7±5.7^c,f	2.3±0.6^d	0.6±0.2
Shock+Terli	2.2±0.3	1.8±0.8^a	0.8±0.2^h	0.9±0.3	1.5±0.7
UClV (mEq/period)
Sham	2.2±1.2	4.3±1.7	1.9±0.5	1.7±0.3	1.5±0.8
Shock-only	3.9±0.9	1.6±0.4	0.3±0.2	0.2±0.1	0
Shock+LRS	1.5±0.3	1.4±0.4	19.5±4.9^b,e	3.7±1.3	0.4±0.2
Shock+Terli	2.7±0.6	1.3±0.6	0.6±0.2ⁱ	0.6±0.2	1.1±0.5
UMgV (mg/period)
Sham	3.2±1.3	1.8±0.4	1.5±0.9	1.2±0.4	0.7±0.5
Shock-only	6.3±1.5	1.2±0.2	0.1±0.4	0.3±0.1	0
Shock+LRS	3.7±0.7	2.2±0.6	9.1±1.6^b,f	2.2±0.7	0.4±0.2
Shock+Terli	5.2±0.9	1.6±0.5	2.6±1.0ⁱ	2.0±0.6	3.3±0.8
UPV (mg/period)
Sham	1.7±1.4	11.3±6.3	7.4±3.8	7.9±3.3	3.2±1.6
Shock-only	4.3±2.3	4.7±2.1	1.2±0.8	0.2±0.2	0
Shock+LRS	1.9±1.2	7.8±2.5	74.1±20.8^b,d	14±4.6^d	3.8±3.0
Shock+Terli	3.3±1.6	2.4±1.4	6.1±3.04^h	7.4±3.3	14.2±12.2
UureaV (mg/period)
Sham	184.4±49.3	371.8±88.1	223.8±66.6	210.4±43.4	162.9±113.1
Shock-only	489.5±82.9	117±22.9^a	18.3±7.9	15.5±2.2^a	0
Shock+LRS	203.7±31.1	140.9±280.6^a	468.5±98.8^a,e	193.4±48.6^d	64.6±28.2
Shock+Terli	428.3±94.3	194.9±77.8	103.3±24.4ⁱ	87.6±27.9	282.6±103.6
Uosm (mOsm/kg)
Sham	735.8±96.1	748.7±102.3	739±85.7	734.6±90.6	617.5±59.5
Shock-only	563.4±95.7	592.6±65.5	446.5±154.5^a	541.3±92.2	793±0.0
Shock+LRS	621.0±39.6	629.3±37.3	368.6±15.5^c	464.7±27.8^b	462.8±25.5
Shock+Terli	659.0±46.8	693.5±45.9	593.4±54.4^b	522±39.5^a	653±91.2

Values are mean±SE.
^ap<0.05 vs sham; ^bp<0.01 vs sham; ^cp<0.001 vs sham; ^dp<0.05 vs shock-only; ^ep<0.01 vs shock-only; ^fp<0.001 vs shock-only; ^gp<0.05 vs shock+LRS; ^hp<0.01 vs shock+LR; ⁱp<0.001 vs shock+LRS.
Sham, anesthetized but not subjected to hemorrhagic shock; Shock+LRS, subjected to hemorrhagic shock and subsequently treated with LRS at a volume equal to three times that of the blood removed; Shock+Terli, subjected to hemorrhagic shock and subsequently treated with a 2 mg bolus of terlipressin; Shock30, 30 min after achieving the target MAP (immediately prior to treatment); Shock-only, subjected to hemorrhagic shock and left untreated; T120, 120 min after treatment; T30, 30 min after treatment; T60, 60 min after treatment; UClV, urinary excretion of chloride; UKV, urinary excretion of potassium; UMgV, urinary excretion of magnesium; UNaV, urinary excretion of sodium; Uosm, urine osmolality; UureaV, urinary excretion of urea.