Table 1

Warfarin reversal protocol (Elvis Presley Trauma Center, Memphis, TN)

First-line recommendation
Vitamin KINR≤2, no vitamin K
INR 2–5, 1–3 mg IV
INR 5–9, 2–5 mg IV
INR>9, 10 mg IV
If INR>2 at 24 hours, repeat vitamin K
PCCFor INR>2, 25–50 U/kg IV
If INR>2 after 1 hour, repeat dose
Second-line recommendation
FFPFor INR>2, 2–4 units of IV
If INR>2 after 1 hour, repeat dose
  • INR, international normalized ratio; IV, intravenous; FFP, fresh frozen plasma; PCC, prothrombin complex concentrate.