PT  - JOURNAL ARTICLE
AU  - Lena M Napolitano
TI  - Prehospital tranexamic acid: what is the current evidence?
AID  - 10.1136/tsaco-2016-000056
DP  - 2017 Jan 01
TA  - Trauma Surgery & Acute Care Open
PG  - e000056
VI  - 2
IP  - 1
4099  - http://tsaco.bmj.com/content/2/1/e000056.short
4100  - http://tsaco.bmj.com/content/2/1/e000056.full
AB  - Many trauma systems are examining whether to implement prehospital tranexamic acid (TXA) protocols since hemorrhage remains the leading cause of potentially preventable early trauma mortality, and early in-hospital administration of TXA within 3 hours of injury is associated with reduced mortality. But robust evidence regarding the efficacy of prehospital administration of the antifibrinolytic drug TXA on trauma outcomes is lacking. This review examines the current evidence available regarding prehospital TXA efficacy in both military and civilian trauma, and updates available evidence regarding in-hospital TXA efficacy in trauma.