Discussion
This secondary analysis of 9551 older patients with EGS conditions showed that age >80 years, admission through the ER, higher CCI scores, and developing complications were associated with primary index admission 30-day inpatient mortality. Older patients admitted through ERs had a lower mean survival time than those admitted through CCs. Among the various complications, patients with cardiac arrest and septic shock had the lowest 30-day mean survival time. Moreover, self-paid patients had higher odds of morbidity, but no significant association with mortality compared with privately insured older patients. Pre-existing comorbidities also increased the risk of mortality. Furthermore, surgical intervention for an EGS diagnosis significantly decreased complications and mortality. Surgical intervention was also influenced by insurance status, where self-paid older patients were operated less frequently compared to privately insured older patients.
Our study showed that patients aged >80 years were associated with a higher mortality risk than those aged 60 to 79 years. This finding is consistent with literature showing an increasing risk of post-EGS mortality with age.25 Furthermore, older age in EGS patients is correlated with worse health outcomes, owing to a higher prevalence of comorbid conditions in this age group.26 An estimated 40% of all EGS index admissions comprise the older population with multiple comorbidities, frailty, and social vulnerabilities such as financial issues. These factors have been shown to amplify poor health outcomes.7 22 23 Additionally, 40% of deaths in such cases occur within 30 days after EGS, 50% develop postoperative complications, and 20% of patients are readmitted within 30 days of the initial discharge.13 27 28
Older patients admitted through ERs had a reduced survival time compared to those admitted through clinics in our study. Patients admitted through clinics have optimal time to undergo a comprehensive assessment and management of comorbidities before admission.29 In contrast, patients admitted from the ER leave little to no time for presurgical evaluation, including data collection of pertinent variables such as area of residence, financial status, and CCI index, which are strong predictors of surgical and overall healthcare outcomes.30 As a result, the lack of comprehensive preoperative information increases vulnerabilities in the older population to known and unknown insults during their hospital stay. This underscores the need for focusing on improving the quality of life alongside addressing life-threatening conditions. Subsequently, the measurable health benefits derived from increased access to surgical care will underscore the value of insurance expansion for such care, particularly for uninsured patients.31
Although pre-existing health conditions are an important predictor of mortality, it is also significantly influenced by complications. Our study highlights that patients experiencing cardiac arrest during hospitalization had the least survival time for both operated and non-operated patients. Research also suggests cardiac arrest to be the leading cause of mortality globally in EGS.32 In such situations, younger patients receive more preference for cardiopulmonary resuscitation and aggressive medical care compared to older patients.33 This might cause increased mortality in older patients with cardiac arrest after general surgery.34 Other reasons could be attributed to increasing age and characteristics of the cardiac arrest itself.35 Furthermore, contrary to our results, a prospective study conducted in Finland concluded septic shock as one of the insignificant causes of in-hospital mortality in older patients who underwent emergency GI surgery. However, septic shock was the common cause of mortality among older patients who died.36
Furthermore, our study showed higher odds of complications in self-paid individuals compared with privately insured patients after an EGS admission. This suggests that the presence of insurance with healthcare service utilization is also strongly associated with inpatient morbidity. However, healthcare coverage was not associated with mortality. This is inconsistent with a recent study conducted in the USA which showed that Medicare (a government national health insurance program) was associated with similar odds of EGS-related mortality as that of medical patients and 30% lower hospitalization rates.37 Another cross-sectional study highlighted that Medicare beneficiaries had fewer deaths, even for the sickest patients in the ER.38 This shows that Medicare-insured beneficiaries had better outcomes. For context, the average cost of outpatient consultation at our institution is US$18. The costs of other procedures are as follows: laparoscopic cholecystectomy is US$1056.43, hernia repair is US$704.29, exploratory laparotomy is US$1056.43, and excisional wound debridement is US$528.22. Our results also highlighted a 13% higher risk of mortality in self-paid individuals. Having insured healthcare is a privilege in LMICs, where most people end up paying out of pocket for their healthcare expenses,39 leading to an increased risk of catastrophic financial losses. This disparity results in self-paid older EGS patients presenting with more complex diseases in the ER, ultimately resulting in greater morbidity and mortality rates.40 Older patients are neglected when it comes to healthcare coverage since there is no financial support provided to them by third-party payors, and younger patients are given preference over elderly patients, which makes the latter at high risk and vulnerable to poor clinical outcomes.41 Our findings also showed that older self-paid patients had significantly higher odds of developing complications than insured patients. These findings are consistent with another study from the USA that showed Medicare self-paid patients had 24% higher odds of developing complications.42 In this regard, working toward attaining universal health coverage is imperative for reducing financial risk and ensuring the provision of essential healthcare services for all, including vulnerable populations.39
Our results showed that the CCI score was associated with mortality in EGS patients. A retrospective study conducted in Massachusetts showed that for patients undergoing high-risk EGS procedures, the odds of mortality with increasing CCI scores increased by 15%.43 The odds remained 17% higher in patients who underwent low-risk procedures for EGS. Another study showed that multiple comorbidities present additional survival risks for older patients than a single comorbidity.44 This is because acute surgical disease and pre-existing conditions/diseases interact and increase the risk of poor patient outcomes, especially in the older population. Our data highlighted that, although the documentation of comorbidities provides an insight about the presence of diseases, it does not give insight into how well they are managed. This in turn leads to in-hospital and postdischarge complications. Literature highlights that the best way to improve outcomes in patients is to increase access to primary care and better manage comorbidities to mitigate emergencies and improve overall patient outcomes.45
Surgical intervention in patients requiring EGS reduced our cohort’s odds of complications and mortality risk. Literature suggests that non-operative management of EGS patients directly increases the risk of mortality at 30 days and 1 year.46 A possible explanation is that the baseline frailty in non-operated patients leads to higher Surgical Risk Calculator scores, outweighing the benefits of undergoing a surgical intervention.47 In contrast, managing high-risk EGS patients operatively does not guarantee their full recovery, and they may also be at risk of long-term functional decline, dependency, and mortality.48 49 Our findings also highlighted a significant difference between patients undergoing surgical interventions and their insurance status. Self-paid individuals are less operated on compared with insured individuals due to the financial pressure on patients without insurance. A study from the USA highlighted that self-paid patients are charged 2.5 times higher for all hospital services as compared to insured patients, resulting in worse outcomes.50
This study presents data on diverse EGS conditions in the older population. It correlates the findings with various complications, providing a holistic view of EGS-related outcomes in this population. However, there are a few limitations to this study. First, the study used data from a single healthcare center in Pakistan, which may impact the generalizability of the findings. However, since this is one of the largest tertiary care hospitals in the country, catering to a vast network of referral hospitals and national and international patients, the sample can be deemed nationally representative. In addition, patients who were alive at the time of discharge but may have passed away in other hospitals within 30 days were not captured in the analysis. However, since our findings corroborate with already published literature from various regions, the results from this study can potentially be extrapolated to similar low-resource settings. Due to the retrospective nature of the study design, our analysis was limited by the number of preoperative variables available. Therefore, variables such as patients’ ethnicity, nutritional assessment, functional status, transfer information, frailty, and addictions could not be assessed. In addition, our data did not provide information on mortality that occurred after 30 days, suggesting that long-term mortality could not be measured, which is a better measure to assess difference in access to care. Furthermore, we used diagnostic codes that do not account for disease severity apart from comorbidities influencing the prediction of primary index admission inpatient mortality. Moreover, the CCI appears quite consistent across groups, exhibiting statistical differences primarily driven by large sample sizes and category combinations. In clinical terms, these distinctions are minimal. It is plausible, although not discernible from this data set, that the management of these comorbidities significantly varies when insurance coverage is absent.
In conclusion, there is considerable variability in EGS procedures; they occur unexpectedly, require urgent medical care, and present minimal opportunity to ensure presurgical care optimization. Pre-existing comorbidities, specific patient characteristics, and the occurrence of complications strongly predict the overall health outcomes in older EGS patients. To improve the overall outcomes of older patients admitted to the hospital following an EGS condition, there is a need to improve access to primary care and manage comorbidities alongside presenting complaints. Given the increasing vulnerabilities in the neglected and high-risk elderly population, there is a dire need to deploy tailored initiatives for older patients undergoing EGS in LMICs. Government efforts to broaden insurance coverage for the elderly can have a positive impact on their healthcare accessibility, thereby reducing the likelihood of essential medical interventions being denied because of financial constraints.