Beta blockers in traumatic brain injury: a systematic review and meta-analysis
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    Correspondence on "Beta blockers in traumatic brain injury: a systematic review and meta-analysis"

    Dear "Trauma Surgery & Acute Care Open,"
    I have perused the article titled "Beta blockers in traumatic brain injury: a systematic review and meta-analysis" with great enthusiasm (Hart et al., 2023). The study's findings present a promising foundation for future research endeavors, shedding light on the effects of beta blockers in the context of traumatic brain injury (TBI). The inclusion of a substantial sample size, totaling 13,244 individuals, bolsters the study's credibility. Nevertheless, it is essential to acknowledge the study's notable limitations, some of which could be addressed with relative ease. Therefore, I urge the authors to carefully consider the following remarks.
    The meta-analysis employed by Hart et al. involved the use of ratios, such as odds ratio and risk ratio, to explore the relationship between interventions and outcomes. However, this method introduces certain biases that undermine the reliability of the findings due to loss of information that could have been used in other methodologies. For instance, the study fails to disclose crucial details regarding the drugs utilized in each study, their respective dosages, and the timing of administration. To compound this issue, these crucial pieces of information are neither provided in a table nor utilized in the meta-analysis. Consequently, the study leaves readers with unexplored sources of heterogeneity, which could have been addressed through subgro...

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    Conflict of Interest:
    None declared.