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Prospective observational study of point-of-care creatinine in trauma
  1. Anthony J Carden1,
  2. Edgardo S Salcedo1,
  3. Nam K Tran2,
  4. Eric Gross3,
  5. Jennifer Mattice3,
  6. Jan Shepard3,
  7. Joseph M Galante1
  1. 1Department of Surgery, Division of Trauma and Acute Care Surgery, UC Davis Medical Center, Sacramento, California, USA
  2. 2Department of Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, California, USA
  3. 3Department of Emergency Medicine, UC Davis Medical Center, Sacramento, California, USA
  1. Correspondence to Dr Anthony J Carden; acarden{at}


Background Patients with trauma are at risk for renal dysfunction from hypovolemia or urological injury. In austere environments, creatinine values are not available to guide resuscitation. A new portable device, the Stat Sensor Point-of-care (POC) Whole Blood Creatinine Analyzer, provides accurate results in <30 s and requires minimal training. This device has not been evaluated in trauma despite the theoretical benefit it provides. The purpose of this study is to determine the clinical impact of the POC device in trauma.

Methods 40 patients with trauma were enrolled in a prospective observational study. One drop of blood was used for creatinine determination on the Statsensor POC device. POC creatinine results were compared to the laboratory. Turnaround time (TAT) for POC and laboratory methods was calculated as well as time elapsed to CT scan if applicable.

Results Patients (n=40) were enrolled between December 2014 and March 2015. POC creatinine values were similar to laboratory methods with a mean bias of 0.075±0.27 (p=0.08). Mean analytical TATs for the POC measurements were significantly faster than the laboratory method (11.6±10.0 min vs 78.1±27.9 min, n=40, p<0.0001). Mean elapsed time before arrival at the CT scanner was 52.9±34.2 min.

Conclusions The POC device reported similar creatinine values to the laboratory and provided significantly faster results. POC creatinine testing is a promising development for trauma practice in austere environments and workup of a subset of stable patients with trauma. Further study is warranted to determine clinical impact, both in hospital-based trauma and austere environments.

  • laboratory
  • Creatinine
  • Point-of-care testing
  • renal function

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