Correct answer C
The patient was diagnosed with a necrotizing soft tissue infection (NSTI) of the left chest wall with associated empyema. Vancomycin and piperacillin/tazobactam were administered, and he was taken to the operating room for exploration and debridement. He was found to have extensive necrosis of the subcutaneous tissues, pectoralis major, and most of his pectoralis minor, all of which were debrided. The infection was contiguous with a large empyema. The chest wall was packed and a chest tube placed. Cultures grew methicillin-resistant Staphylococcus aureus (MRSA). He underwent daily serial debridements of his chest wall and decortication on day 3. Final pathology was consistent with a NSTI. His chest wall defect was managed with a negative pressure dressing (figure 2). He was discharged to a rehabilitation facility with a negative pressure dressing to the left chest 18 days after presentation. After 2 months, he underwent a latissimus dorsi flap for chest wall reconstruction (figure 3).
Figure 2The patient underwent serial debridements and pleural cavity drainage. After surgical control of the necrotizing soft tissue infection, the chest wall wound healed well and was treated with a negative-pressure dressing changes. Here is a photo of the wound 5 days after initiation of wound vacuum assisted closure (VAC) therapy. There is extensive granulation tissue at the base of the wound and no residual necrotic tissue.
Figure 3Two months after initial presentation. Left chest wall following reconstruction with a pedicled latissimus dorsi flap.
NSTIs are rare but serious infections associated with a significant morbidity and mortality. Despite improvements in the diagnosis and treatment, mortality remains high (16.9–29%). Early recognition and prompt surgical intervention decrease mortality. Factors that suggest a necrotizing infection include exquisite tenderness to palpation, marked erythema, crepitus, and bullae. Patients often manifest signs of sepsis and septic shock. Laboratory abnormalities include leucocytosis, neutrophilia, and hyponatremia.
Few reports describe NSTI of the chest, most of which are due to penetrating trauma or chest tube placement. It is possible that this patients' infection originated from an infected hematoma or pneumonia, which expanded outward from the pleural space into the chest wall. The current literature cites an exceptionally high mortality after NSTI of the chest wall (60–89%). The higher mortality of chest wall NSTI is due to the impact of aggressive debridement on chest wall mechanics. Maintenance of chest wall integrity improves outcomes and should be attempted in order to allow proper ventilation and recovery.
The development of NSTI after empyema or hemothorax is extremely rare. It is prudent to drain empyemas to facilitate recovery, yet some patients have pleural collections that remain undrained with satisfactory clinical outcome. To the best of our knowledge, there are no data that estimate the risk of development of NSTI after empyema whether drained or undrained.
Overall, this case represents an extremely unique presentation of chest wall NSTI. While most cases of NSTI of the chest are incited by iatrogenic procedures, this NSTI developed secondary to a presumed undrained empyema, which may have been related to pneumonia with superinfection of a small hemothorax. Currently, little data exist on the relationship between empyema and subsequent NSTI. Future studies should evaluate this relative risk in order to help guide the future management of such pleural collections and decrease the morbidity and mortality from highly lethal chest wall NSTIs.