Prior to 2001 there was no standard for early management of severe sepsis and septic shock
in the emergency department. In the presence of standard or usual care, the prevailing …

Background The comparative efficacy and safety of balanced crystalloid solutions and saline
for fluid therapy in critically ill adults remain uncertain. Methods We systematically reviewed …

… The individual colloids have different rates of loss from the circulation (determined by
molecular weight) and metabolism (determined by chemical properties), which influence the …

Background Both balanced crystalloids and saline are used for intravenous fluid administration
in critically ill adults, but it is not known which results in better clinical outcomes. Methods …

Background Whether video laryngoscopy as compared with direct laryngoscopy increases
the likelihood of successful tracheal intubation on the first attempt among critically ill adults is …

… Semler, MD 39 ; David E. Leaf, MD, MMSc 1 ; for the STOP-COVID Investigators … Dr
Semler reported receiving grants from the NIH/NHLBI during the conduct of the study. No other …

Importance Therapies that improve survival in critically ill patients with coronavirus disease
2019 (COVID-19) are needed. Tocilizumab, a monoclonal antibody against the interleukin 6 …

… Dr Semler reported receiving grants from the NHLBI during the conduct of the study. Dr
Leither reported receiving grants from the NHLBI during the conduct of the study. Dr Casey …

Background Comparative clinical effects of balanced crystalloids and saline are uncertain,
particularly in noncritically ill patients cared for outside an intensive care unit (ICU). Methods …

Background Invasive mechanical ventilation in critically ill adults involves adjusting the
fraction of inspired oxygen to maintain arterial oxygen saturation. The oxygen-saturation target …