REVIEW Bcl-2 and related cytoplasmic proteins are key regulators of apoptosis, the cell suicide
program critical for development, tissue homeostasis, and protection against pathogens. …

… & Adams, JM Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-Myc
to immortalize pre-B cells. Nature 335, 440–442 (1988).Discovery that Bcl2 promotes cell …

The BCL-2 protein family determines the commitment of cells to apoptosis, an ancient cell
suicide programme that is essential for development, tissue homeostasis and immunity. Too …

A common feature of follicular lymphoma, the most prevalent haematological malignancy in
humans, is a chromosome translocation (t(14;18)) that has coupled the immunoglobulin …

Impaired apoptosis is both critical in cancer development and a major barrier to effective
treatment. In response to diverse intracellular damage signals, including those evoked by …

Transgenic mice bearing the cellular myc oncogene coupled to the immunoglobulin μ or κ
enhancer frequently develop a fatal lymphoma within a few months of birth. Since the tumours …

… tively or promiscuously is important for clarifying how cell death initiates (Adams, 2003)
and is … Coultas, L., Bouillet, P., Stanley, EG, Brodnicki, TC, Adams, JM, were derived from …

Apoptosis, the cell-suicide programme executed by caspases, is critical for maintaining tissue
homeostasis, and impaired apoptosis is now recognized to be a key step in tumorigenesis. …

Apoptosis can be triggered by members of the Bcl-2 protein family, such as Bim, that share
only the BH3 domain with this family. Gene targeting in mice revealed important physiological …

Apoptosis provoked by DNA damage requires the p53 tumor suppressor, but which of the
many p53-regulated genes are required has remained unknown. Two genes induced by this …