Importance Severely injured patients experiencing hemorrhagic shock often require massive
transfusion. Earlier transfusion with higher blood product ratios (plasma, platelets, and red …

Background The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
on postoperative recovery needs to be understood to inform clinical decision making during …

Sepsis remains a highly lethal entity resulting in more than 200 000 deaths in the USA each
year. The in-hospital mortality approaches 30% despite advances in critical care during the …

The use of digital technology is increasing rapidly across surgical specialities, yet there is no
consensus for the term 'digital surgery'. This is critical as digital health technologies present …

BACKGROUND Historically, hemorrhage has been attributed as the leading cause (40%) of
early death. However, a rigorous, real-time classification of the cause of death (COD) has …

Background Recent studies have demonstrated the vital influence of commensal microbial
communities on human health. The central role of the gut in the response to injury is well …

BACKGROUND Early predictors of massive transfusion (MT) would prevent undertriage of
patients likely to require MT. This study validates triggers using the Prospective …

BACKGROUND Although obese patients have high thrombosis rates following injury, the
role of obesity in coagulation after trauma remains unknown. We hypothesized that body …

BACKGROUND Trauma-induced coagulopathy is a major driver of mortality following
severe injury. Viscoelastic goal-directed resuscitation can reduce mortality after injury. The …

BACKGROUND Severely injured patients often progress from early hypocoagulable to
normal and eventually hypercoagulable states, developing increased risk for venous …