Donor issueInfluence of Donor Characteristics on Outcome After Lung Transplantation: A Multicenter Study
Section snippets
Material and methods
We used data collected as part of the study of the predictive factors of early mortality after LT designed by the French Lung Transplantation Group.14 The medical records of all adult patients who underwent single LT (SLT), bilateral LT (BLT), or heart LT (HLT) in 7 centers in France from January 1988 to December 1998 were retrospectively reviewed.
Results
During the study period (1988–1998), 785 patients underwent LT and met the selection criteria for the study. On the whole collected data, 4% were missing. Underlying diseases and surgical techniques differed markedly between centers. There were 270 SLT (178 right, 92 left), 251 BLT (82 en bloc, 169 sequential), and 264 HLT. Cardiopulmonary bypass was required in 494 cases (63.6%). In case of HLT or en bloc BLT, cardiopulmonary bypass was used in all cases; it was used in 93 cases (55.7%) of
Discussion
Since the first report in 1993 of a small series of lung transplantations performed with marginal donors,8 several small monocentric retrospective studies have focused on their use.9, 10, 11, 12, 13 All but one13 have yielded encouraging results in terms of early gas exchange, postoperative complications, pulmonary function, and mortality. On the basis of these articles, several authors advocate the liberalization of lung-donor selection criteria.
All the literature cited above used the same
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Cited by (72)
Donor Selection and Management
2021, Encyclopedia of Respiratory Medicine, Second EditionSuboptimal Donors Do Not Mean Worse Results: A Single-Center Study of Extending Donor Criteria for Lung Transplant
2020, Transplantation ProceedingsCitation Excerpt :Its conclusion states that majority of articles report comparably positive outcomes of lung transplant after donation from donors of oxygenation index of less than 300 mm Hg [11]. On the other hand, the nonlinear model of Thalbut et al showed a steep increase in the relative risk of death when donor PaO2/FiO2 before harvest was below 350 mm Hg [12]. However, available data of more recent studies and review assessing greater number of patients rule in favor of extending the oxygenation index values as well as taking a more liberal approach on its importance.
Perioperative Considerations Regarding Sex in Solid Organ Transplantation
2020, Anesthesiology ClinicsCOLT: Ten years of research in lung transplantation, results and perspectives
2018, Revue des Maladies RespiratoiresRisk Factor Analysis for Intraoperative Extracorporeal Membrane Oxygenation Weaning Failure After Lung Transplantation
2018, Annals of Thoracic SurgeryCitation Excerpt :Although the importance of donor Pao2 has been less emphasized than in the past, this factor remains one of the most important criteria for donor lungs. Indeed, recipient Pao2 is known to be roughly proportional to donor Pao2 mm Hg [22, 23]. Considering allograft function is partially decreased by ischemic reperfusion injury during the transplant procedure, a high donor Pao2 can reduce the risk of prolonged ECMO care for insufficient arterial saturation.