Dabigatran | Rivaroxaban | Apixaban | |
---|---|---|---|
Mechanism of action | Thrombin inhibitor | Factor Xa inhibitor | Factor Xa inhibitor |
T1/2 (hours) | 12–14 | 9–13 | 8–15 |
Regimen | BID | QID | BID |
Time to peak (hours) | 1 | 2–4 | 3 |
Renal excretion | 80% | 40% | 25% |
Metabolism and uptake | P-glycoprotein | CY3A4 and P-glycoprotein | CY3A4 and P-glycoprotein |
BID, twice daily; QID, four times a day.