TY - JOUR T1 - Impact thromboelastometry (ITEM) for point-of-injury detection of trauma-induced coagulopathy: a pilot study JF - Trauma Surgery & Acute Care Open DO - 10.1136/tsaco-2016-000049 VL - 2 IS - 1 SP - e000049 AU - Gerard S Doyle AU - Aristotle A Theodore AU - J Nicholas Hansen Y1 - 2017/03/01 UR - http://tsaco.bmj.com/content/2/1/e000049.abstract N2 - Background Acute coagulopathy of trauma is associated with high mortality and extensive use of blood products. Hemostatic resuscitation, the early administration of blood products with higher ratios of procoagulant components, may improve trauma outcomes in select cases, but can also worsen outcome if inappropriately used. Evolving approaches to hemostatic resuscitation utilize viscoelastic tests to provide a more rational basis for choosing blood component therapy regimens, but these tests are logistically rigorous. We hypothesized that coagulopathy could be detected by the failure of blood clots to remain intact when subjected to a predefined impact force.Methods We aim to develop a point-of-injury test for coagulopathy. We created coagulopathic blood using an ex vivo normal saline (NS) dilution model and allowed blood of varying dilutions to clot, then examined the behavior of the clotted blood when subjected to a uniform gravitationally induced sheer force.Results Clots created from coagulopatic blood (diluted to ≤50% with NS) failed under gravitational challenge at a significantly higher rate than non-coagulopathic blood dilutions.Discussion Impact thromboelastometry (ITEM) represents a simple, logistically lean method for detecting dilutional coagulopathy that may facilitate detection of trauma-induced coagulopathy. ITEM may thus function as a point-of-injury or point-of-care screening test for the presence of coagulopathy.Level of evidence Diagnostic studies, Level IV. ER -